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High Functionality Excipients - HiCelTM SMCC

The properties of microcrystalline cellulose have been tried to improve by co-processing MCC with colloidal silicon dioxide. HiCelTM SMCC is silicified microcrystalline cellulose, a combination of 98% microcrystalline cellulose (MCC) and 2% colloidal silicon dioxide (CSD). HiCelTM SMCC has unique combination which result in optimum compaction and superior flow properties.

Advantages

Grades & Applications

Silicified microcrystalline cellulose (SMCC) should have better compaction properties and it is more resistant to wet granulation than conventional MCC grades.

SMCC Grade Average Particle Size (┬Ám) Applications
HiCelTM SMCC 50 60
  • In direct compression when optimum compaction and decent flow is required
  • In direct compression when optimum compaction and decent flow is required
  • Extrusion / Spheronization .
HiCelTM SMCC 90 110
  • Tablet binder in direct compression where optimum flow is required
  • As a filler in capsule
  • Low dose content uniformity
HiCelTM SMCC HD 90 110
  • Ready-to-use or reconstitutable, where the drug is mixed with other ingredients in the dry state and reconstituted with water at the time of dispensing to the patient
  • Improve tablet disintegration
  • High dose capsule filling
  • Increase batch size due to high bulk density
HiCelTM SMCC LM 90 110
  • Tablet binder in direct compression of water sensitive actives
  • As a filler in capsule
  • Low dose content uniformity