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High Functionality Excipients - HiCelTM SMCC

The properties of microcrystalline cellulose have been tried to improve by co-processing MCC with colloidal silicon dioxide. HiCelTM SMCC is silicified microcrystalline cellulose, a combination of 98% microcrystalline cellulose (MCC) and 2% colloidal silicon dioxide (CSD). HiCelTM SMCC has unique combination which result in optimum compaction and superior flow properties.

Advantages

Grades & Applications

Silicified microcrystalline cellulose (SMCC) should have better compaction properties and it is more resistant to wet granulation than conventional MCC grades.

SMCC Grade Average Particle Size (µm) Applications
HiCelTM SMCC 50 60
  • In direct compression when optimum compaction and decent flow is required
  • In direct compression when optimum compaction and decent flow is required
  • Extrusion / Spheronization .
HiCelTM SMCC 90 110
  • Tablet binder in direct compression where optimum flow is required
  • As a filler in capsule
  • Low dose content uniformity
HiCelTM SMCC HD 90 110
  • Ready-to-use or reconstitutable, where the drug is mixed with other ingredients in the dry state and reconstituted with water at the time of dispensing to the patient
  • Improve tablet disintegration
  • High dose capsule filling
  • Increase batch size due to high bulk density
HiCelTM SMCC LM 90 110
  • Tablet binder in direct compression of water sensitive actives
  • As a filler in capsule
  • Low dose content uniformity