Sigachi Industries Ltd > Pharmaceutical Industry > Binders > HiCel™

The HiCelTM brand of Microcrystalline Cellulose is by far the most consistent brand in the Cellulose industry. HiCelTM is spray dried directly compressible form of MCC . HiCelTM is available in several grades which varies in their average particle size moisture content and bulk density

ADVANTAGES

The Functionality in Pharma Applications are
  • As a Strong, dry binder
  • High dilution potential
  • Good compressibility
  • Broad particle size distribution
  • Low bulk density
  • Provides for high tablet hardness at low pressure
    • high porosity
    • plastic deformation
  • Facilitates low tablet friabilityPromotes rapid tablet disintegration
  • Good flowability
  • Less glidant requirement
  • Lower tablet weight variation
  • Anti-adherent and inherent lubrication, can reduce lubricant requirement

GRADES

The various Grade of HiCelTM are as under
Grade Description Applications
HiCel™ 50M MCC 101
  • Because of its small particle size, can be used for both wet and dry granulation. Effective when used with large particles because of is binding properties. Primary use is in the wet granulation applications.
HiCel™ 90M MCC 102
  • Has larger particle size, improved flowability, especially with smaller particle size components. Most popular grade of MCC used in direct compression.
HiCel™ LP200 MCC 200
  • Large particle size used with poorly flowing actives. Improves flowability& facilitates high speed tableting of direct compression blends and reduces tablet weight variation.
HiCel™ XLM 90 Low moisture MCC 102
  • Equal to grade 102/90M, but low moisture content (<1.5%) It is recommended for extremely moisture sensitive active ingredient .
HiCel™ XLM 50 Low moisture MCC 101
  • Equal to grade 101/50M, but low moisture content (<1.5%). It is recommended for extremely moisture sensitive active ingredient.
HiCel™ XLM 200 Low moisture MCC 200
  • Equal to grade LP200, but low moisture content (<1.5%). It is recommended for extremely moisture sensitive active ingredient.
HiCel™ 25M MCC 105
  • Finest grade for chewable tablets. Improves texture and compressibility. It gives a pleasant mouth feel, masks bitter tastes & supports flavors.
HiCel™ 12 MCC 12
  • Coarse grade MCC, combines good compatibility & high binding capacity with outstanding flow, provides good content uniformity at low weight variation even when used with low concentration of fine actives.
HiCel™ 14 Low moisture MCC 12
  • Equal to grade HiCel™ 12, but low moisture content (<1.5%) It is recommended for extremely moisture sensitive active ingredient.
HiCel™ HD50M MCC 301
  • Similar to 50M & 90M in particle size, but with higher densities. Both grades have improve flowability and facilitate thinner tablets.
HiCel™ HD90M MCC 302
HiCel™ 90M SCG
  • Coarser than HiCel™ MCC 90M and fine than HiCel™ MCC LP200 .This grade has been specially developed for high density with fine particles API’.

PHARMACEUTICAL APPLICATIONS

INDUSTRIES

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